RAF Typhoon jets have operated alongside French aircraft in a combined operation on an underground arms cache in Syria operated by the IS group, per a report from the British defence ministry.
The facility, identified by surveillance, was thought to be housing weapons and explosive materials, the statement said, and was positioned in hills just above the historic site of Palmyra in central Syria.
"Our aircraft used Paveway IV guided bombs to hit a number of approach shafts providing entry to the depot... initial indications are that the target was engaged successfully," the MoD said.
There was no indication of any harm to civilians in the strike conducted Saturday night and all the aircraft returned safely, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
IS - referred to as Daesh - imposed jihadist rule over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This strike underscores the UK's leading role, and resolve to operate in unison with allied nations, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the region," UK Defence Secretary John Healey remarked.
British military aircraft have conducted overwatch operations over Syria to "deter any efforts to regroup" of the group subsequent to its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I want to thank all the members of the UK armed forces involved in this operation for their expertise and their bravery," he added. "They were among a great many UK service members stationed over Christmas and New Year. This operation, to take out terrorist threats who pose a risk to our security, shows how UK forces are always on standby, throughout the year, protecting the UK at home and strong abroad."
In December, the United States armed forces executed what it called a "major assault" on Islamic State objectives in the country, subsequent to an ambush claimed the lives of two US servicemembers and a civilian interpreter in the Palmyra area.
The United Nations says Daesh still has an estimated 5,000 to 7,000 fighters in Syria and Iraq.